Gorjestani, Sara

Sara Gorjestani, Ph.D. is a medical research analyst with extensive experience in biomedical science research in the fields of cancer biology and immunology. Her work focuses on analyzing scientific research articles, medical records and related literature for fact investigation and discovery. She prepares medical analyses and summaries, examination outlines and reliance materials, and provides trial support.

Sara has authored numerous scientific publications, presented her work at scientific conferences, and is the recipient of a National Research Service Award.

Peer-reviewed journals in which Sara's work appears include:

Nature
The Journal of Experimental Medicine
Cancer Discovery
European Journal of Immunology
The Journal of Biological Chemistry

Previous Experience

Postdoctoral Fellow, National Institutes of Health (NIH), Ruth L. Kirschstein National Research Service Award (NRSA) University of California, San Diego

Highlighted Publications

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3Kγ is a molecular switch that controls immune suppression.. Nature. (November 2016) 17;539(7629):437-442
Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. "Bruton's Tyrosine Kinase (BTK)-dependent immune cell crosstalk drives pancreas cancer," Cancer Discovery (Dec. 29, 2015)
Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ. "Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9," European Journal of Immunology 45 2 (February 2015): 513-24
Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin X. "CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for anti-fungal immunity," The Journal of Experimental Medicine 211, 11 (Oct. 20, 2014): 2307-21
Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X, Dong C. "USP18 inhibits NF-KB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex," The Journal of Experimental Medicine 210, 8 (July 29, 2013): 1575-90
Gorjestani S, Darnay BG, Lin X. "Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGF6-activated Kinase 1(TAK1) Play Essential Roles in the c-type Lectin Receptor Signaling in Response to Candida albicans Infection," The Journal of Biological Chemistry 287, 53 (Dec. 28, 2012): 44143-50 PMID: 23148225
Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X. "Phospholipase Cγ2 (PLCγ2) is a key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses," J. Biol. Chem. 286, 51 (Dec. 23, 2011): 43651-9 PMID: 22041900
Bi L, Gorjestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. "CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans," J. Biol. Chem. 285, 34 (Aug. 20, 2010): 25969-77 PMID: 20538615
Gorjestani S, Rider V, Kimler BF, Greenwell C, Abdou NI. "Extracellular signal-regulated kinase 1/2 signaling in SLE T cells is influenced by oestrogen and disease activity," Lupus 17, 6 (2008): 548-54 PMID: 18539